Daniele Manfredini received his DDS from the University of Pisa, Italy in 1999, a MSc in Occlusion and Craniomandibular Disorders in 2001 from the same University, a PhD in Dentistry from the ACTA Amsterdam, The Netherlands, in 2011, and a Post-Graduation Specialty in Orthodontics from the University of Ferrara, Italy, in 2017. He achieved the Diplomate Status from the American Board of Orofacial Pain in 2021. He is an active Member of the European Academy of Orofacial Pain and Dysfunction (former EACD) and Fellow of the American Academy of Orofacial Pain. He is Founder Member of the Italian Society of Prosthodontics and Oral Rehabilitation (SIPRO), and President of the Italian Study Group on Orofacial Pain (GSID).

He was a clinical fellow at the Section of Prosthetic Dentistry, Department of Neuroscience, University of Pisa, Italy until 2005. From 2006 to 2016, Daniele Manfredini has been Assistant Professor at the School of Dentistry and coordinator of the research projects at the TMD Clinic, Department of Maxillofacial Surgery, University of Padova, Italy

On January 2017, the Italian Ministry of University and Research (MIUR) appointed him as a Full Professor by scientific merit at the age of 41.
Currently, Daniele Manfredini serves as Professor at the School of Dentistry, University of Siena, Italy, where he has held teachings in Oral Physiology and in Clinical Gnathology since 2017.

Daniele Manfredini authored more than 250 papers in the field of bruxism and temporomandibular disorders in journals indexed in the Medline database (Scopus H-index=53). He also edited, among the others, the book “Current concepts on temporomandibular disorders” (Quintessence Publishing, 2010), including contributions from 45 world-renowned experts, and co-authored several textbooks on the same topics.
Based on publication ratings, in November 2013, the US agency Expertscape ranked Prof. Manfredini as world #1 expert in the field of temporomandibular joint disorders, and since then he has always been included in the top three experts in the field. Since November 2018, he has also been indicated by the same agency as #1 in the field of bruxism. Since 2018, Daniele Manfredini is Member and Coordinator of the Bruxism Consensus Panel within the International Association for Dental Research, which works on the updated definition and classification strategies for bruxism